Develop the most comprehensive statistical computational models of tissue blocks of WM microstructure and microcirculation to date based on novel human brain histomorphometric data in health and disease state
Deliver the most detailed signal models to date of simultaneous d- and p-weighted MR Gradient Sensitised Imaging (GSI) and robust and consistent estimators to optimally identify these model parameters
Design a set of optimal gradient-sensitising directions and pulse sequence that harmonise constraints on optimal sensing and hardware demands enabling use across the widest range of clinical MR scanners
Develop tissue biomimetic brain phantoms based on polymer materials with dimensions, p and barrier permeabilities in the range of axons in WM serving as gold-standard for both p/d MRI
Demonstrate the accuracy of the proposed technique in high-resolution imaging of brain tissue blocks and biomimetic brain phantoms; demonstrate feasibility and clinical potential in a small patient cohort
News
On the 05/11/2015 CISTIB hosted and ran a meeting of the Diffusion MRI UK Group (www.diffusion-mri.org.uk). Alongside this in the morning the scientific committee of the new research project OCEAN (www.ocean-mri.org) which is being led by CISTIB met with many of the attendees took part in the Diffusion MRI UK meeting in the afternoon. This meeting drew together researchers from the field of Diffusion MRI this included academics and PhD students from different institutes. The day included poster and talks given by both senior academics and... |